Influenza: H3N2 Subclade K (The 2025-26 Emerging Health Threat) Influenza: H3N2 Subclade K (The 2025-26 Emerging Health Threat) By Azeem-USA The 2025-26 influenza season has been characterized by an unusually early and aggressive increase in activity across the Northern Hemisphere. Public health surveillance networks began detecting a sharp rise in cases as early as mid-November, diverging from the more typical late-winter peaks. This shift is primarily driven by the global dominance of a newly emerged variant within the A(H3N2) lineage: Subclade K (J.2.4.1) . This variant has demonstrated a remarkable capacity for transmission, quickly outcompeting other lineages to become the primary driver of medically attended respiratory illness this season. As an epidemiologist monitoring these genomic shifts, it is clear that Subclade K presents unique...
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